Cognitive rejuvenation through OSK-mediated gene therapy in dementia
A webinar by Prof. Johannes Gräff, EPFL
Restoring seemingly lost bodily functions in age and age-related disorders has, over recent years, transitioned from the realm of science fiction to tangible research questions with high translational potential. Among the available approaches, partial cellular reprogramming has emerged as one of the most promising strategies to promote tissue regeneration and restore cellular function, while at the same time preserving cellular identities. However, whether this approach bears fruit to rejuvenate cognitive processes has remained unknown until recently.
In this talk, will highlight recent findings from his laboratory, which show that partial reprogramming of engram neurons – bona fide memory trace cells – by OSK-mediated gene therapy leads to cognitive rejuvenation. This intervention reverses the expression of senescence and disease-related cellular hallmarks in aged mice and models of Alzheimer’s disease (AD), re-establishes aberrant epigenetic-transcriptional patterns pertaining to synaptic plasticity and counteracts AD-typical neuronal hyperexcitability. Importantly, irrespective of the brain area targeted or the behavioural paradigm employed, engram reprogramming also restores learning and memory capacities to levels comparable of healthy young animals. These results posit that partial reprogramming of defined cell populations in the brain can be translationally exploited for cognitive restoration in aging and disease.
Event details:
- Date: 28.05.2026
- Time: 16:00
- Duration: 45 minutes (includes Q&A)
- Location: Online (link to be provided upon registration)
- Costs: Free of charge
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The Dementia Update - Virtual Series is a monthly online event designed to promote knowledge exchange among experts in neurodegenerative disorders. It brings together researchers, clinicians, caregivers and industry professionals to share the latest research, and innovations. Each 45-minute session features a presentation, offering a platform for networking, idea exchange and exploring future collaborations.
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About the speaker
Prof. Johannes Gräff is featured on our community platform’s expert list. Visit his profile to explore his research interests, ongoing projects, publications, and potential collaboration opportunities.
