Ultrasound-mediated blood-brain barrier opening: A novel approach for neurodegenerative disease therapy

The treatment of brain diseases remains challenging due to the difficulty of delivering therapeutics across the blood-brain barrier (BBB). While several methods have been developed to improve brain penetration, most of them require chemical/structural modifications of the original compound, often at the expense of its therapeutic efficacy. These led the field to rely on intrathecal (IT) injection to allow direct diffusion of therapeutics into the central nervous system to access their targets. However, this strategy comes with several aversive effects for the patients, and with potential health risks.

Low-intensity pulsed ultrasound (LIPU), combined with intravenously administered microbubbles, is a method to temporarily disrupt the BBB and enhance drug delivery. This strategy allows the free passage of a large range of therapeutics and clinical studies have reported a 4 to 5-fold increase in brain concentrations of drugs. This new opportunity for drug delivery could bring more comfort for the patients during their medical care without compromising the efficacy of the treatment.

Event details:

• Date: 27.11.2025
• Time: 16:00
• Duration: 45 minutes (includes Q&A)
• Location: Online (link to be provided upon registration)
• Costs: Free of charge

Register today:

The Dementia Update - Virtual Series is a monthly online event designed to promote knowledge exchange among experts in neurodegenerative disorders. It brings together researchers, clinicians, caregivers and industry professionals to share the latest research, and innovations. Each 45-minute session features a presentation, offering a platform for networking, idea exchange and exploring future collaborations.

Be part of this exciting virtual session and secure your spot!